Assay Detail
Functional
CHEMBL814912
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Tested in vitro for trypanocidal activity against KETRI 243 an uncloned clinical isolate of Trypanosoma brucei. rhodesiense
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.11 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86281 | — | — | 1 | 6.85 |
| CHEMBL85189 | — | — | 1 | 6.80 |
| CHEMBL84221 | — | — | 1 | 6.80 |
| CHEMBL82641 | — | — | 1 | 6.44 |
| CHEMBL85198 | — | — | 1 | 6.28 |
| CHEMBL62048 | — | — | 1 | 6.10 |
| CHEMBL86096 | — | — | 1 | 5.82 |
| CHEMBL85161 | — | — | 1 | 5.47 |
| CHEMBL310207 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86281 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL85189 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL84221 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL82641 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL85198 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL62048 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL86096 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL85161 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL310207 | — | IC50 | = | 35000.0 | nM | 4.46 |