Assay Detail
Functional
CHEMBL814915
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Antitrypanosomal activity against Trypanosoma brucei.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.67 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333481 | — | — | 1 | 7.00 |
| CHEMBL119649 | — | — | 1 | 6.52 |
| CHEMBL118915 | — | — | 1 | 6.40 |
| CHEMBL443023 | — | — | 1 | 6.16 |
| CHEMBL432423 | — | — | 1 | 6.10 |
| CHEMBL118340 | — | — | 1 | 6.00 |
| CHEMBL117926 | — | — | 1 | 6.00 |
| CHEMBL440898 | — | — | 1 | 6.00 |
| CHEMBL117064 | — | — | 1 | 5.89 |
| CHEMBL118916 | — | — | 1 | 5.89 |
| CHEMBL119096 | CRYPTOLEPINE | — | 1 | 5.52 |
| CHEMBL119102 | — | — | 1 | 5.40 |
| CHEMBL118066 | — | — | 1 | 5.40 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.40 |
| CHEMBL118838 | — | — | 1 | 5.03 |
| CHEMBL118855 | — | — | 1 | 4.84 |
| CHEMBL118165 | — | — | 1 | 4.78 |
| CHEMBL115433 | — | — | 1 | 4.78 |
| CHEMBL332478 | — | — | 1 | 4.56 |
| CHEMBL118343 | — | — | 1 | - |
| CHEMBL332113 | — | — | 1 | - |
| CHEMBL331251 | — | — | 1 | - |
| CHEMBL119834 | — | — | 1 | - |
| CHEMBL119475 | — | — | 1 | - |
| CHEMBL117831 | — | — | 1 | - |
| CHEMBL323909 | — | — | 1 | - |
| CHEMBL115592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333481 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL119649 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL118915 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL443023 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL432423 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL118340 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL117926 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL440898 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL117064 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL118916 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL119096 | CRYPTOLEPINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119102 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118066 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118838 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL118855 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL118165 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL115433 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL332478 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL118343 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL332113 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL331251 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL119834 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL119475 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL117831 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL323909 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL115592 | — | IC50 | > | 32000.0 | nM | - |