Assay Detail
Functional
CHEMBL815215
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In vitro growth inhibitory activity against Trypanosoma brucei strain LAB110
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.68 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44025 | — | — | 1 | 7.51 |
| CHEMBL41629 | — | — | 1 | 6.90 |
| CHEMBL289450 | — | — | 1 | 6.62 |
| CHEMBL43495 | — | — | 1 | 6.51 |
| CHEMBL43390 | — | — | 1 | 5.49 |
| CHEMBL296119 | — | — | 1 | 5.39 |
| CHEMBL40258 | — | — | 1 | 4.84 |
| CHEMBL416078 | — | — | 1 | 4.75 |
| CHEMBL296777 | — | — | 1 | 4.66 |
| CHEMBL44039 | — | — | 1 | 4.14 |
| CHEMBL43494 | — | — | 1 | - |
| CHEMBL44040 | — | — | 1 | - |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | — | 2 | - |
| CHEMBL40414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44025 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL41629 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL289450 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL43495 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL43390 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL296119 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL40258 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL416078 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL296777 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL44039 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL43494 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44040 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL40414 | — | IC50 | > | 100000.0 | nM | - |