Assay Detail
Functional
CHEMBL815219
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Inhibition of Trypanosoma brucei rhodesiense growth
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.25 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137641 | — | — | 1 | 6.00 |
| CHEMBL138230 | — | — | 1 | 6.00 |
| CHEMBL334695 | — | — | 1 | 6.00 |
| CHEMBL31547 | — | — | 1 | 5.70 |
| CHEMBL31235 | — | — | 1 | 5.70 |
| CHEMBL137305 | — | — | 1 | 5.40 |
| CHEMBL31946 | — | — | 1 | 5.30 |
| CHEMBL274031 | — | — | 1 | 5.30 |
| CHEMBL285209 | — | — | 1 | 5.30 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.16 |
| CHEMBL326989 | — | — | 1 | 5.00 |
| CHEMBL343127 | — | — | 1 | 4.89 |
| CHEMBL334919 | — | — | 1 | 4.85 |
| CHEMBL137448 | — | — | 1 | 4.68 |
| CHEMBL343271 | — | — | 1 | 4.62 |
| CHEMBL30734 | — | — | 1 | 4.11 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL18967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137641 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL138230 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL334695 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL31547 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL31235 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL137305 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL31946 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL274031 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL285209 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL326989 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL343127 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL334919 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL137448 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL343271 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL30734 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 148000.0 | nM | - |
| CHEMBL18967 | — | IC50 | = | 204000.0 | nM | - |