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Assay Detail

CHEMBL815464

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Functional
In vitro antiparasitic activity was determined against Trypanosoma brucei
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Expert

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
Dardonville C, Rinaldi E, Barrett MP, Brun R, Gilbert IH, Hanau S.
J Med Chem (2004) 47 : 3427 -3437
PubMed 15189039 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.37 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117535 1 5.46
CHEMBL325269 1 4.44
CHEMBL420687 1 4.33
CHEMBL113666 1 4.31
CHEMBL116390 1 4.22
CHEMBL114160 1 4.21
CHEMBL116897 1 4.14
CHEMBL325268 1 4.12
CHEMBL114616 1 4.09
CHEMBL114894 1 -
CHEMBL324609 1 -
CHEMBL113708 1 -
CHEMBL117133 1 -
CHEMBL117876 1 -
CHEMBL114269 1 -
CHEMBL116018 1 -
CHEMBL334040 1 -
CHEMBL117442 1 -
CHEMBL117534 1 -
CHEMBL323922 1 -
CHEMBL113843 1 -
CHEMBL116916 1 -
CHEMBL114416 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117535 IC50 = 3500.0 nM 5.46
CHEMBL325269 IC50 = 36000.0 nM 4.44
CHEMBL420687 IC50 = 47000.0 nM 4.33
CHEMBL113666 IC50 = 49000.0 nM 4.31
CHEMBL116390 IC50 = 60000.0 nM 4.22
CHEMBL114160 IC50 = 61000.0 nM 4.21
CHEMBL116897 IC50 = 73000.0 nM 4.14
CHEMBL325268 IC50 = 75000.0 nM 4.12
CHEMBL114616 IC50 = 82000.0 nM 4.09
CHEMBL114894 IC50 = 212000.0 nM -
CHEMBL324609 IC50 > 332000.0 nM -
CHEMBL113708 IC50 = 113000.0 nM -
CHEMBL117133 IC50 = 244000.0 nM -
CHEMBL117876 IC50 = 137000.0 nM -
CHEMBL114269 IC50 = 229000.0 nM -
CHEMBL116018 IC50 > 389000.0 nM -
CHEMBL334040 IC50 = 262000.0 nM -
CHEMBL117442 IC50 = 116000.0 nM -
CHEMBL117534 IC50 = 126000.0 nM -
CHEMBL323922 IC50 = 277000.0 nM -
CHEMBL113843 IC50 > 304000.0 nM -
CHEMBL116916 IC50 = 113000.0 nM -
CHEMBL114416 IC50 = 130000.0 nM -