Assay Detail
Binding
CHEMBL815478
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In Vitro inhibition of Thymidine Monophosphatase Kinase (TMPKh)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.65 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161004 | — | — | 1 | 5.33 |
| CHEMBL1160994 | — | — | 1 | 4.50 |
| CHEMBL1160993 | — | — | 1 | 4.40 |
| CHEMBL1161003 | — | — | 1 | 4.36 |
| CHEMBL124682 | — | — | 1 | - |
| CHEMBL124260 | — | — | 1 | - |
| CHEMBL340604 | — | — | 1 | - |
| CHEMBL1161001 | — | — | 1 | - |
| CHEMBL127523 | — | — | 1 | - |
| CHEMBL341264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161004 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL1160994 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL1160993 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1161003 | — | Ki | = | 43500.0 | nM | 4.36 |
| CHEMBL124682 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL124260 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL340604 | — | Ki | = | 1040000.0 | nM | - |
| CHEMBL1161001 | — | Ki | = | 280000.0 | nM | - |
| CHEMBL127523 | — | Ki | = | 970000.0 | nM | - |
| CHEMBL341264 | — | Ki | = | 220000.0 | nM | - |