Assay Detail
Binding
CHEMBL815506
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Compound was evaluated for the inhibition of Escherichia coli Thymidylate Synthase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.61 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.52 |
| CHEMBL25889 | — | — | 1 | 7.35 |
| CHEMBL330484 | — | — | 1 | 5.82 |
| CHEMBL90795 | — | — | 1 | 5.73 |
| CHEMBL329619 | — | — | 1 | - |
| CHEMBL92589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL25889 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL330484 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL90795 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL329619 | — | IC50 | = | 201000.0 | nM | - |
| CHEMBL92589 | — | IC50 | = | 515000.0 | nM | - |