Assay Detail
Binding
CHEMBL816562
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Inhibitory activity against thrombin
49
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 6.97 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107392 | — | — | 1 | 8.68 |
| CHEMBL104192 | — | — | 1 | 8.48 |
| CHEMBL107627 | — | — | 1 | 8.40 |
| CHEMBL421411 | — | — | 1 | 8.37 |
| CHEMBL107743 | — | — | 1 | 8.28 |
| CHEMBL51173 | — | — | 1 | 8.22 |
| CHEMBL97597 | — | — | 1 | 8.21 |
| CHEMBL317199 | — | — | 1 | 8.13 |
| CHEMBL262805 | — | — | 1 | 8.06 |
| CHEMBL322901 | — | — | 1 | 7.92 |
| CHEMBL319035 | — | — | 1 | 7.92 |
| CHEMBL318177 | — | — | 2 | 7.92 |
| CHEMBL107911 | — | — | 1 | 7.80 |
| CHEMBL320393 | — | — | 1 | 7.72 |
| CHEMBL106718 | — | — | 1 | 7.66 |
| CHEMBL322165 | — | — | 1 | 7.64 |
| CHEMBL107188 | — | — | 1 | 7.64 |
| CHEMBL320937 | — | — | 1 | 7.62 |
| CHEMBL321162 | — | — | 1 | 7.58 |
| CHEMBL105439 | — | — | 1 | 7.50 |
| CHEMBL107429 | — | — | 1 | 7.44 |
| CHEMBL420476 | — | — | 1 | 7.43 |
| CHEMBL107282 | — | — | 1 | 7.43 |
| CHEMBL318175 | — | — | 1 | 7.39 |
| CHEMBL323304 | — | — | 1 | 7.36 |
| CHEMBL104872 | — | — | 1 | 7.24 |
| CHEMBL104241 | — | — | 1 | 7.19 |
| CHEMBL104930 | — | — | 1 | 6.66 |
| CHEMBL107132 | — | — | 1 | 6.55 |
| CHEMBL318304 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107392 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL104192 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL107627 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL421411 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL107743 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL51173 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL97597 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL317199 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL262805 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL322901 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL318177 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL319035 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL107911 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL320393 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL106718 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL322165 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL107188 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL320937 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL321162 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL318177 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL105439 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL107429 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL107282 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL420476 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL318175 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL323304 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL104872 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL104241 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL104930 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL318304 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL107132 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL322404 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL318352 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL105569 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL323101 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL319868 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL107522 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL104970 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL322437 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL450936 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL106111 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL104815 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL104157 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL326013 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL320512 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL104426 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL411506 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL322622 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL317271 | — | Ki | = | 36000.0 | nM | 4.44 |