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Assay Detail

CHEMBL816564

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory effect against bovine thrombin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prothrombin (CHEMBL4471)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Rational design of selective thrombin inhibitors
Kim S, Hwang SY, Kim YK, Yun M, Oh YS
Bioorg Med Chem Lett (1997) 7 : 769 -774
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.89 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL353818 1 9.00
CHEMBL347158 1 8.83
CHEMBL51173 1 8.19
CHEMBL354307 1 7.70
CHEMBL165909 1 7.34
CHEMBL164512 1 7.30
CHEMBL349986 1 7.28
CHEMBL165781 1 5.94
CHEMBL349483 1 5.57
CHEMBL424164 1 5.37
CHEMBL165413 1 5.27
CHEMBL163147 1 4.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL353818 Ki = 1.0 nM 9.00
CHEMBL347158 Ki = 1.47 nM 8.83
CHEMBL51173 Ki = 6.5 nM 8.19
CHEMBL354307 Ki = 20.0 nM 7.70
CHEMBL165909 Ki = 45.5 nM 7.34
CHEMBL164512 Ki = 50.0 nM 7.30
CHEMBL349986 Ki = 52.4 nM 7.28
CHEMBL165781 Ki = 1140.0 nM 5.94
CHEMBL349483 Ki = 2700.0 nM 5.57
CHEMBL424164 Ki = 4320.0 nM 5.37
CHEMBL165413 Ki = 5370.0 nM 5.27
CHEMBL163147 Ki = 13600.0 nM 4.87