Assay Detail
Binding
CHEMBL816696
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Tested for inhibition of protein tyrosine kinase c-Src phosphorylation
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176702 | — | — | 1 | 8.00 |
| CHEMBL367442 | — | — | 1 | 7.70 |
| CHEMBL175409 | — | — | 1 | 7.70 |
| CHEMBL424375 | — | — | 1 | 7.52 |
| CHEMBL105436 | — | — | 1 | 7.52 |
| CHEMBL173453 | — | — | 1 | 7.52 |
| CHEMBL172973 | — | — | 1 | 7.30 |
| CHEMBL173478 | — | — | 1 | 7.22 |
| CHEMBL176815 | — | — | 1 | 7.22 |
| CHEMBL169757 | — | — | 1 | 7.00 |
| CHEMBL176705 | — | — | 1 | 6.82 |
| CHEMBL176309 | — | — | 1 | 6.70 |
| CHEMBL429057 | — | — | 1 | 6.52 |
| CHEMBL176470 | — | — | 1 | 5.30 |
| CHEMBL174634 | — | — | 1 | 5.22 |
| CHEMBL426229 | — | — | 1 | 5.10 |
| CHEMBL369014 | — | — | 1 | 5.00 |
| CHEMBL173474 | — | — | 1 | 5.00 |
| CHEMBL366831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176702 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL367442 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL175409 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL424375 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL105436 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL173453 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL172973 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL173478 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL176815 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL169757 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL176705 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL176309 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL429057 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL176470 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL174634 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL426229 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL369014 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL173474 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL366831 | — | IC50 | > | 10000.0 | nM | - |