Assay Detail
Binding
CHEMBL816697
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Inhibition of chicken c-Src tyrosine kinase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.36 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 8.05 |
| CHEMBL297523 | — | — | 1 | 8.05 |
| CHEMBL50647 | — | — | 1 | 8.00 |
| CHEMBL51283 | — | — | 1 | 8.00 |
| CHEMBL45827 | — | — | 1 | 7.64 |
| CHEMBL301612 | — | — | 1 | 7.62 |
| CHEMBL432314 | — | — | 1 | 7.62 |
| CHEMBL298679 | — | — | 1 | 7.55 |
| CHEMBL51485 | — | — | 1 | 7.52 |
| CHEMBL51028 | — | — | 1 | 7.51 |
| CHEMBL299194 | — | — | 1 | 6.62 |
| CHEMBL49596 | — | — | 1 | 6.58 |
| CHEMBL48172 | — | — | 1 | 6.28 |
| CHEMBL50470 | — | — | 1 | 6.02 |
| CHEMBL299763 | — | — | 1 | - |
| CHEMBL49658 | — | — | 1 | - |
| CHEMBL296540 | — | — | 1 | - |
| CHEMBL48809 | — | — | 1 | - |
| CHEMBL51573 | — | — | 1 | - |
| CHEMBL50977 | — | — | 1 | - |
| CHEMBL299347 | — | — | 1 | - |
| CHEMBL50371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49120 | PD-0166285 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL297523 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL50647 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL51283 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL45827 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL301612 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL432314 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL298679 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL51485 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL51028 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL299194 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL49596 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL48172 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL50470 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL49658 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL296540 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL48809 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL51573 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL299347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50371 | — | IC50 | > | 50000.0 | nM | - |