Assay Detail
Functional
CHEMBL817404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth inhibition of bloodstream-form Trypanosoma brucei rhodesiense Trypomastigotes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.01 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434024 | — | — | 1 | 6.66 |
| CHEMBL55557 | — | — | 1 | 6.21 |
| CHEMBL55140 | — | — | 1 | 6.16 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 6.02 |
| CHEMBL293522 | — | — | 1 | 5.77 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.77 |
| CHEMBL416301 | — | — | 1 | 5.70 |
| CHEMBL55812 | OLPADRONIC ACID | 2.0 | 1 | 5.27 |
| CHEMBL55358 | — | — | 1 | 5.11 |
| CHEMBL298852 | — | — | 1 | 5.10 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.07 |
| CHEMBL301247 | — | — | 1 | 5.07 |
| CHEMBL55359 | — | — | 1 | 4.70 |
| CHEMBL54004 | — | — | 1 | 4.69 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.68 |
| CHEMBL56556 | — | — | 1 | 4.67 |
| CHEMBL55214 | NERIDRONIC ACID | 3.0 | 1 | 4.50 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.46 |
| CHEMBL417932 | — | — | 1 | 4.40 |
| CHEMBL100483 | — | — | 1 | 4.40 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.30 |
| CHEMBL54714 | — | — | 1 | 4.27 |
| CHEMBL299988 | — | — | 1 | 4.21 |
| CHEMBL52761 | — | — | 1 | 4.04 |
| CHEMBL299491 | — | — | 1 | 4.00 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | - |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434024 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL55557 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL55140 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL293522 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL416301 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL55812 | OLPADRONIC ACID | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL55358 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL298852 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL301247 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL55359 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL54004 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL56556 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL55214 | NERIDRONIC ACID | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL417932 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL100483 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL54714 | — | IC50 | = | 53300.0 | nM | 4.27 |
| CHEMBL299988 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL52761 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL299491 | — | IC50 | = | 99800.0 | nM | 4.00 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 102000.0 | nM | - |