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Assay Detail

CHEMBL818209

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Varicella-Zoster virus (YS)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Confidence 1 — Organism
Curated By Intermediate

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity.
Angell A, McGuigan C, Garcia Sevillano L, Snoeck R, Andrei G, De Clercq E, Balzarini J.
Bioorg Med Chem Lett (2004) 14 : 2397 -2399
PubMed 15109620 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 7.28 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL344738 CF1743 1 9.52
CHEMBL3142406 1 8.30
CHEMBL3142404 1 7.85
CHEMBL3142408 1 7.70
CHEMBL3142407 1 7.37
CHEMBL3142401 1 7.22
CHEMBL3142400 1 6.82
CHEMBL3142397 1 6.75
CHEMBL184 ACYCLOVIR 4.0 1 5.82
CHEMBL3142405 1 5.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL344738 CF1743 EC50 = 0.3 nM 9.52
CHEMBL3142406 EC50 = 5.0 nM 8.30
CHEMBL3142404 EC50 = 14.0 nM 7.85
CHEMBL3142408 EC50 = 20.0 nM 7.70
CHEMBL3142407 EC50 = 43.0 nM 7.37
CHEMBL3142401 EC50 = 60.0 nM 7.22
CHEMBL3142400 EC50 = 150.0 nM 6.82
CHEMBL3142397 EC50 = 180.0 nM 6.75
CHEMBL184 ACYCLOVIR EC50 = 1500.0 nM 5.82
CHEMBL3142405 EC50 = 3400.0 nM 5.47