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Assay Detail

CHEMBL818253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Serine protease 1 (CHEMBL3769)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS
von der Saal W, Kucznierz R, Leinert H, Engh RA
Bioorg Med Chem Lett (1997) 7 : 1283 -1288
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.46 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51173 1 6.16
CHEMBL24827 1 5.77
CHEMBL20936 BENZAMIDINE 1 4.46
CHEMBL284348 DALFAMPRIDINE 4.0 1 -
CHEMBL24479 1 -
CHEMBL285311 1 -
CHEMBL23813 1 -
CHEMBL23468 1 -
CHEMBL281715 1 -
CHEMBL25835 1 -
CHEMBL282549 1 -
CHEMBL23300 1 -
CHEMBL23246 1 -
CHEMBL25890 1 -
CHEMBL23243 1 -
CHEMBL23252 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51173 Ki = 690.0 nM 6.16
CHEMBL24827 Ki = 1700.0 nM 5.77
CHEMBL20936 BENZAMIDINE Ki = 35000.0 nM 4.46
CHEMBL284348 DALFAMPRIDINE Ki > 2000000.0 nM -
CHEMBL24479 Ki > 500000.0 nM -
CHEMBL285311 Ki > 500000.0 nM -
CHEMBL23813 Ki > 500000.0 nM -
CHEMBL23468 Ki > 500000.0 nM -
CHEMBL281715 Ki > 500000.0 nM -
CHEMBL25835 Ki > 500000.0 nM -
CHEMBL282549 Ki > 500000.0 nM -
CHEMBL23300 Ki > 500000.0 nM -
CHEMBL23246 Ki > 500000.0 nM -
CHEMBL25890 Ki > 500000.0 nM -
CHEMBL23243 Ki > 500000.0 nM -
CHEMBL23252 Ki > 500000.0 nM -