Assay Detail
Functional
CHEMBL818299
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Effective concentration against TK+ Varicella-Zoster Virus (VZV) OKA strain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.14 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146350 | — | — | 1 | 8.30 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.30 |
| CHEMBL344107 | — | — | 1 | 6.80 |
| CHEMBL413063 | — | — | 1 | 6.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146350 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL344107 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL413063 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 2400.0 | nM | 5.62 |