Assay Detail
Functional
CHEMBL818302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against TK- Varicella-Zoster Virus (VZV) YS/R strain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.21 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344107 | — | — | 1 | 5.52 |
| CHEMBL413063 | — | — | 1 | 5.40 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.72 |
| CHEMBL146350 | — | — | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344107 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL413063 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL146350 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | EC50 | > | 150000.0 | nM | - |