Assay Detail
Functional
CHEMBL819836
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against epimastigote form of Trypanosoma cruzi
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.64 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339048 | — | — | 1 | 5.30 |
| CHEMBL434816 | — | — | 1 | 4.85 |
| CHEMBL39581 | — | — | 1 | 4.80 |
| CHEMBL128211 | — | — | 1 | 4.56 |
| CHEMBL129569 | — | — | 1 | 4.39 |
| CHEMBL340071 | — | — | 1 | 4.33 |
| CHEMBL128963 | — | — | 1 | 4.23 |
| CHEMBL132400 | — | — | 1 | - |
| CHEMBL128441 | — | — | 1 | - |
| CHEMBL129012 | — | — | 1 | - |
| CHEMBL128021 | — | — | 1 | - |
| CHEMBL131106 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339048 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL434816 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL39581 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL128211 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL129569 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL340071 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL128963 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL132400 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL128441 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL129012 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL128021 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL131106 | — | IC50 | > | 70000.0 | nM | - |