Assay Detail
Binding
CHEMBL821236
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Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Interaction of 1-(5-phospho-beta-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-beta-D-arabinosyl)-5-fluorouracil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.98 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 8.00 |
| CHEMBL603555 | — | — | 1 | 6.60 |
| CHEMBL235506 | — | — | 1 | 4.80 |
| CHEMBL603336 | — | — | 1 | 4.52 |
| CHEMBL606019 | — | — | 1 | - |
| CHEMBL2311177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL603555 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL235506 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL603336 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL606019 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL2311177 | — | Ki | = | 120000.0 | nM | - |