Assay Detail
Functional
CHEMBL822039
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Dose inhibiting the ionotropic response induced by hCGRP-alpha in guinea pig left atrium.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.15 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369459 | — | — | 1 | 8.06 |
| CHEMBL2369464 | — | — | 1 | 7.52 |
| CHEMBL2369465 | — | — | 1 | 7.24 |
| CHEMBL2369452 | — | — | 1 | 7.19 |
| CHEMBL2369457 | — | — | 1 | 7.05 |
| CHEMBL2369454 | — | — | 1 | 7.02 |
| CHEMBL2369458 | — | — | 1 | 6.93 |
| CHEMBL525571 | — | — | 1 | 6.71 |
| CHEMBL2369463 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369459 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2369464 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2369465 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2369452 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2369457 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2369454 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2369458 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL525571 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2369463 | — | EC50 | = | 215.0 | nM | 6.67 |