Assay Detail
Functional
CHEMBL822170
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Tested for the alpha-2-adrenoceptor blocking activity by antagonism of clonidine-induced depression of the twitch responses of the field-stimulated prostatic portion of isolated rat vas deferens
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.74 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.01 |
| CHEMBL39745 | — | — | 1 | 6.46 |
| CHEMBL25554 | — | — | 1 | 6.39 |
| CHEMBL286329 | — | — | 1 | 5.94 |
| CHEMBL286673 | — | — | 1 | 5.76 |
| CHEMBL289428 | — | — | 1 | 5.70 |
| CHEMBL36738 | — | — | 1 | 4.87 |
| CHEMBL286565 | — | — | 1 | 4.37 |
| CHEMBL287935 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10316 | IDAZOXAN | Kd | = | 9.772 | nM | 8.01 |
| CHEMBL39745 | — | Kd | = | 346.74 | nM | 6.46 |
| CHEMBL25554 | — | Kd | = | 407.38 | nM | 6.39 |
| CHEMBL286329 | — | Kd | = | 1148.15 | nM | 5.94 |
| CHEMBL286673 | — | Kd | = | 1737.8 | nM | 5.76 |
| CHEMBL289428 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL36738 | — | Kd | = | 13489.63 | nM | 4.87 |
| CHEMBL286565 | — | Kd | = | 42657.95 | nM | 4.37 |
| CHEMBL287935 | — | Kd | = | 66069.34 | nM | 4.18 |