Assay Detail
Functional
CHEMBL822209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose inhibiting the ionotropic response induced by hCGRP-alpha in guinea pig right atrium.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.96 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369459 | — | — | 1 | 8.10 |
| CHEMBL2369464 | — | — | 1 | 7.05 |
| CHEMBL2369465 | — | — | 1 | 6.97 |
| CHEMBL2369452 | — | — | 1 | 6.94 |
| CHEMBL2369457 | — | — | 1 | 6.94 |
| CHEMBL2369454 | — | — | 1 | 6.75 |
| CHEMBL2369458 | — | — | 1 | 6.71 |
| CHEMBL2369463 | — | — | 1 | 6.65 |
| CHEMBL525571 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369459 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL2369464 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2369465 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2369452 | — | EC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2369457 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL2369454 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL2369458 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL2369463 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL525571 | — | EC50 | = | 267.0 | nM | 6.57 |