Assay Detail
Functional
CHEMBL822271
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Evaluated for the anti-VZV activity, the concentration of compounds in uM required to reduce VZV OKA Plaque formation after 5 days in HEL cell cultures compared to untreated controls.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.96 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344738 | CF1743 | — | 1 | 9.52 |
| CHEMBL147862 | — | — | 1 | 9.30 |
| CHEMBL146212 | — | — | 1 | 8.66 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.52 |
| CHEMBL144792 | — | — | 1 | 8.27 |
| CHEMBL147162 | — | — | 1 | 8.00 |
| CHEMBL144817 | — | — | 1 | 7.82 |
| CHEMBL146310 | — | — | 1 | 7.70 |
| CHEMBL147046 | — | — | 1 | 7.40 |
| CHEMBL342980 | — | — | 1 | 7.05 |
| CHEMBL145868 | — | — | 1 | 7.00 |
| CHEMBL359446 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344738 | CF1743 | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL147862 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL146212 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL144792 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL147162 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL144817 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL146310 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL147046 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL342980 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL145868 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL359446 | — | EC50 | = | 500.0 | nM | 6.30 |