Assay Detail
Functional
CHEMBL822723
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Antinociceptive activity determined in vivo in tail flick assay in male Swiss mice with 2.0 mg/kg Naloxone
3
Total Activities
3
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Tail |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.89 | 10.05 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 2.0 | mg.kg-1 | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 10.05 |
| CHEMBL290543 | — | — | 1 | 9.82 |
| CHEMBL52307 | — | — | 1 | 9.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL290543 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL52307 | — | Ki | = | 0.16 | nM | 9.80 |