Assay Detail
Functional
CHEMBL822947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Steroid potentiation of 5% GABA responses in Xenopus oocytes expressing human alpha-1-beta-2-gamma-2L subunits of GABA-A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095172) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.60 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138009 | — | — | 1 | 8.18 |
| CHEMBL3138433 | — | — | 1 | 8.09 |
| CHEMBL3138291 | — | — | 1 | 7.75 |
| CHEMBL3138293 | — | — | 1 | 7.51 |
| CHEMBL3138017 | — | — | 1 | 6.47 |
| CHEMBL3138315 | — | — | 1 | - |
| CHEMBL3138292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138009 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3138433 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL3138291 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3138293 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3138017 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3138315 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3138292 | — | EC50 | > | 1000.0 | nM | - |