Assay Detail
Functional
CHEMBL823359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of currents generated by 50 uM kainate in Xenopus oocytes injected with rat brain mRNA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283350 | — | — | 1 | 8.30 |
| CHEMBL282030 | — | — | 1 | 8.22 |
| CHEMBL19194 | — | — | 1 | 7.66 |
| CHEMBL277281 | — | — | 1 | 7.54 |
| CHEMBL273569 | — | — | 1 | 7.52 |
| CHEMBL19892 | FANAPANEL | 2.0 | 1 | 7.51 |
| CHEMBL277340 | — | — | 1 | 7.22 |
| CHEMBL281393 | — | — | 1 | 6.89 |
| CHEMBL277711 | — | — | 1 | 6.89 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 6.63 |
| CHEMBL13260 | YM-90K | — | 1 | 6.58 |
| CHEMBL19857 | — | — | 1 | 6.50 |
| CHEMBL279116 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283350 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL282030 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL19194 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL277281 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL273569 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL19892 | FANAPANEL | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL277340 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL281393 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL277711 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL13260 | YM-90K | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL19857 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL279116 | — | IC50 | = | 1800.0 | nM | 5.75 |