Compound Detail
CHEMBL19892
FANAPANEL 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL19892 |
| Name | FANAPANEL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WZMQMKNCWDCCMT-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
3
Known Names
Molecular Properties
409.3
MW (Da)
0.68
ALogP
6
HBA
3
HBD
124.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 6 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Xenopus sp. CHEMBL612667 | IC50 | 7.51 | 7.51 | 31.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.92 | 6.26 | 120.0 | 2 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.55 | 5.42 | 2800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Xenopus sp. | IC50 | = | 31.0 | nM | 7.51 | Inhibition of currents generated by 50 uM kainate in Xenopus oocytes injected wi... | 11354378 |
| Unchecked | IC50 | = | 120.0 | nM | 6.92 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane | 20356304 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 140.0 | nM | 6.85 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA of rat cortical... | 11354378 |
| Unchecked | IC50 | = | 2500.0 | nM | 5.6 | Displacement of [3H]kainate from kainate receptor in rat cortical membrane | 20356304 |
| Glutamate NMDA receptor | IC50 | = | 2800.0 | nM | 5.55 | Inhibition of NMDA receptor glutamate site from rat cortical membrane | 20356304 |
| Glutamate NMDA receptor | IC50 | = | 5150.0 | nM | 5.29 | Inhibition of NMDA receptor glycine site from rat cortical membrane | 20356304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Mus musculus | 2 |
| 20356304 | 10.1021/jm901688m | Unchecked | 2 |
| 20356304 | 10.1021/jm901688m | Glutamate NMDA receptor | 2 |
| 20356304 | 10.1021/jm901688m | Rattus norvegicus | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 9871630 | 10.1016/s0960-894x(97)10186-x | Glutamate receptor ionotropic, AMPA | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate receptor ionotropic, AMPA | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate NMDA receptor | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Xenopus sp. | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine