Compound Detail
CHEMBL281393
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Basic Information
| ChEMBL ID | CHEMBL281393 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEFXBWCRLKDZEO-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
296.2
MW (Da)
2.72
ALogP
6
HBA
3
HBD
120.0
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Xenopus sp. CHEMBL612667 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.78 | 6.78 | 167.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.23 | 6.23 | 593.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Xenopus sp. | IC50 | = | 130.0 | nM | 6.89 | Inhibition of currents generated by 50 uM kainate in Xenopus oocytes injected wi... | 11354378 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 167.0 | nM | 6.78 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA of rat cortical... | 11354378 |
| Glutamate NMDA receptor | IC50 | = | 593.0 | nM | 6.23 | Displacement of [3H]DCKA from glycine NMDA receptor of rat cortical membranes | 11354378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Mus musculus | 2 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate receptor ionotropic, AMPA | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate NMDA receptor | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Xenopus sp. | 1 |
Data from ChEMBL 36 via Core Engine