Assay Detail
Binding
CHEMBL685092
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Displacement of [3H]DCKA from glycine NMDA receptor of rat cortical membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.53 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273569 | — | — | 1 | 7.75 |
| CHEMBL277340 | — | — | 1 | 7.50 |
| CHEMBL277281 | — | — | 1 | 7.08 |
| CHEMBL19194 | — | — | 1 | 6.87 |
| CHEMBL277711 | — | — | 1 | 6.80 |
| CHEMBL19955 | — | — | 1 | 6.74 |
| CHEMBL282030 | — | — | 1 | 6.64 |
| CHEMBL19857 | — | — | 1 | 6.38 |
| CHEMBL281393 | — | — | 1 | 6.23 |
| CHEMBL283350 | — | — | 1 | 5.85 |
| CHEMBL279116 | — | — | 1 | 5.52 |
| CHEMBL13260 | YM-90K | — | 1 | 4.98 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | - |
| CHEMBL19892 | FANAPANEL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273569 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL277340 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL277281 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL19194 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL277711 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL19955 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL282030 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL19857 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL281393 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL283350 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL279116 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL13260 | YM-90K | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | > | 10000.0 | nM | - |
| CHEMBL19892 | FANAPANEL | IC50 | > | 10000.0 | nM | - |