Compound Detail
CHEMBL19955
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Basic Information
| ChEMBL ID | CHEMBL19955 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AAHYPUHOANEINX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
348.3
MW (Da)
1.60
ALogP
6
HBA
2
HBD
108.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 7.64 | 7.64 | 23.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.74 | 6.74 | 184.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 23.0 | nM | 7.64 | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA of rat cortical... | 11354378 |
| Glutamate NMDA receptor | IC50 | = | 184.0 | nM | 6.74 | Displacement of [3H]DCKA from glycine NMDA receptor of rat cortical membranes | 11354378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Mus musculus | 2 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate receptor ionotropic, AMPA | 1 |
| 11354378 | 10.1016/s0960-894x(01)00180-9 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine