Assay Detail
Functional
CHEMBL823402
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Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Analogues of platelet activating factor. 8. Antagonists of PAF containing an aromatic ring linked to a pyridinium ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.63 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274420 | CV-6209 | — | 1 | 7.70 |
| CHEMBL154282 | — | — | 1 | 7.66 |
| CHEMBL157123 | — | — | 1 | 7.19 |
| CHEMBL349327 | — | — | 1 | 7.00 |
| CHEMBL154536 | — | — | 1 | 6.80 |
| CHEMBL296973 | — | — | 1 | 6.27 |
| CHEMBL154205 | — | — | 1 | 6.02 |
| CHEMBL155590 | — | — | 1 | 6.00 |
| CHEMBL154459 | — | — | 1 | 5.96 |
| CHEMBL296958 | KADSURENONE | — | 1 | 5.48 |
| CHEMBL155663 | — | — | 1 | 5.43 |
| CHEMBL155380 | — | — | 1 | 5.17 |
| CHEMBL157330 | — | — | 1 | 5.08 |
| CHEMBL154537 | — | — | 1 | 5.00 |
| CHEMBL646 | TRIAZOLAM | 4.0 | 1 | 4.96 |
| CHEMBL153901 | — | — | 1 | 4.82 |
| CHEMBL434460 | — | — | 1 | 4.77 |
| CHEMBL156891 | — | — | 1 | 4.70 |
| CHEMBL661 | ALPRAZOLAM | 4.0 | 1 | 4.66 |
| CHEMBL295212 | — | — | 1 | 4.59 |
| CHEMBL347593 | — | — | 1 | 4.37 |
| CHEMBL155500 | — | — | 1 | 4.22 |
| CHEMBL347349 | — | — | 1 | - |
| CHEMBL156823 | — | — | 1 | - |
| CHEMBL349582 | — | — | 1 | - |
| CHEMBL346271 | — | — | 1 | - |
| CHEMBL351759 | — | — | 1 | - |
| CHEMBL154113 | — | — | 1 | - |
| CHEMBL421827 | — | — | 1 | - |
| CHEMBL154591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274420 | CV-6209 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL154282 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL157123 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL349327 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL154536 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL296973 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL154205 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL155590 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL154459 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL296958 | KADSURENONE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL155663 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL155380 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL157330 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL154537 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL646 | TRIAZOLAM | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL153901 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL434460 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL156891 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL661 | ALPRAZOLAM | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL295212 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL347593 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL155500 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL346722 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL351997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL154856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL154993 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL155003 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL422160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL155540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL348589 | — | IC50 | = | 330000.0 | nM | - |
| CHEMBL154591 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421827 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL154113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL351759 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL346271 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL349582 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL156823 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL347349 | — | IC50 | > | 10000.0 | nM | - |