Compound Detail
CHEMBL153901
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Basic Information
| ChEMBL ID | CHEMBL153901 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VLDQGNCAPVXHMQ-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1181049 |
| Active Moiety | CHEMBL1181049 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
467.7
MW (Da)
6.49
ALogP
2
HBA
1
HBD
42.2
PSA (Ų)
0.19
QED
1
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL5136 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma | 8496938 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8496938 | 10.1021/jm00057a008 | Platelet-activating factor receptor | 1 |
Data from ChEMBL 36 via Core Engine