Assay Detail
Binding
CHEMBL823440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cytosolic c-Src
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.77 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57323 | — | — | 1 | 6.96 |
| CHEMBL312454 | — | — | 1 | 6.68 |
| CHEMBL300171 | — | — | 1 | 6.68 |
| CHEMBL57366 | — | — | 1 | 6.66 |
| CHEMBL81615 | — | — | 1 | 6.44 |
| CHEMBL78393 | — | — | 1 | 6.39 |
| CHEMBL77781 | — | — | 1 | 6.10 |
| CHEMBL81975 | — | — | 1 | 5.87 |
| CHEMBL312048 | — | — | 1 | 5.85 |
| CHEMBL312148 | — | — | 1 | 5.78 |
| CHEMBL82431 | — | — | 1 | 5.38 |
| CHEMBL79274 | — | — | 1 | 5.36 |
| CHEMBL79241 | — | — | 1 | 4.98 |
| CHEMBL421145 | — | — | 1 | 4.98 |
| CHEMBL309470 | — | — | 1 | 4.76 |
| CHEMBL76599 | — | — | 1 | 4.71 |
| CHEMBL81146 | — | — | 1 | 4.44 |
| CHEMBL49658 | — | — | 1 | - |
| CHEMBL78555 | — | — | 1 | - |
| CHEMBL56236 | — | — | 1 | - |
| CHEMBL299763 | — | — | 1 | - |
| CHEMBL78485 | — | — | 1 | - |
| CHEMBL78802 | — | — | 1 | - |
| CHEMBL312055 | — | — | 1 | - |
| CHEMBL445893 | — | — | 1 | - |
| CHEMBL48809 | — | — | 1 | - |
| CHEMBL81474 | — | — | 1 | - |
| CHEMBL50371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57323 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL312454 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL300171 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL57366 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL81615 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL78393 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL77781 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL81975 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL312048 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL312148 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL82431 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL79274 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL79241 | — | IC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL421145 | — | IC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL309470 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL76599 | — | IC50 | = | 19330.0 | nM | 4.71 |
| CHEMBL81146 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL49658 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL78555 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL56236 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL299763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL78485 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL78802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL312055 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL445893 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL48809 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL81474 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50371 | — | IC50 | > | 50000.0 | nM | - |