Assay Detail
Functional
CHEMBL824192
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Cytotoxicity against CHO cell line xrs6
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | XRS6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.85 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.62 |
| CHEMBL341831 | — | — | 1 | 5.37 |
| CHEMBL344243 | — | — | 1 | 5.37 |
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 4.64 |
| CHEMBL138922 | — | — | 1 | 4.57 |
| CHEMBL336253 | ADOCIAQUINONE A | — | 1 | 4.11 |
| CHEMBL138236 | — | — | 1 | - |
| CHEMBL344218 | — | — | 1 | - |
| CHEMBL140718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL43 | AMSACRINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL341831 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL344243 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL138922 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL336253 | ADOCIAQUINONE A | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL138236 | — | IC50 | 2727000.0 | nM | - | |
| CHEMBL344218 | — | IC50 | = | 287000.0 | nM | - |
| CHEMBL140718 | — | IC50 | = | 287000.0 | nM | - |