Assay Detail
Functional
CHEMBL824929
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Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI10A cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HBI10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.01 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434340 | — | — | 1 | 6.46 |
| CHEMBL73502 | — | — | 1 | 6.22 |
| CHEMBL179482 | — | — | 1 | 6.10 |
| CHEMBL308370 | — | — | 1 | 5.92 |
| CHEMBL368341 | — | — | 1 | 5.92 |
| CHEMBL176605 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434340 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL73502 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL179482 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL308370 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL368341 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL176605 | — | IC50 | = | 3800.0 | nM | 5.42 |