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Assay Detail

CHEMBL824945

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required for inhibition of glucose stimulated insulin release from beta TC6 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Beta-TC6
Confidence 1 — Organism
Curated By Intermediate

Target

Beta-TC6 (CHEMBL614357)
Type CELL-LINE
Organism Mus musculus

Publication

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.
Nielsen FE, Jacobsen P, Worsaae A, Arkhammar PO, Wahl P, Bondo Hansen J.
Bioorg Med Chem Lett (2004) 14 : 5727 -5730
PubMed 15501029 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.29 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL135191 TIFENAZOXIDE 2.0 1 6.60
CHEMBL112668 1 6.34
CHEMBL185449 1 6.09
CHEMBL182674 1 5.95
CHEMBL180193 1 5.80
CHEMBL183353 1 5.25
CHEMBL181539 1 4.98
CHEMBL181897 1 4.98
CHEMBL185015 1 4.69
CHEMBL181 DIAZOXIDE 4.0 1 4.64
CHEMBL360535 1 4.59
CHEMBL183026 1 4.58
CHEMBL183054 1 4.31
CHEMBL183640 1 -
CHEMBL360298 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL135191 TIFENAZOXIDE IC50 = 250.0 nM 6.60
CHEMBL112668 IC50 = 460.0 nM 6.34
CHEMBL185449 IC50 = 820.0 nM 6.09
CHEMBL182674 IC50 = 1120.0 nM 5.95
CHEMBL180193 IC50 = 1600.0 nM 5.80
CHEMBL183353 IC50 = 5670.0 nM 5.25
CHEMBL181539 IC50 = 10370.0 nM 4.98
CHEMBL181897 IC50 = 10400.0 nM 4.98
CHEMBL185015 IC50 = 20530.0 nM 4.69
CHEMBL181 DIAZOXIDE IC50 = 22980.0 nM 4.64
CHEMBL360535 IC50 = 25740.0 nM 4.59
CHEMBL183026 IC50 = 26620.0 nM 4.58
CHEMBL183054 IC50 = 48540.0 nM 4.31
CHEMBL183640 IC50 - nM -
CHEMBL360298 IC50 - nM -