Compound Detail
CHEMBL183054
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Basic Information
| ChEMBL ID | CHEMBL183054 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RUENBLUYNLWOPN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
4.62
ALogP
5
HBA
1
HBD
80.6
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Beta-TC6 CHEMBL614357 | IC50 | 4.31 | 4.31 | 48540.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 2500.0 | nM | 5.6 | inhibitory concentration required for repolarization of beta cell membrane poten... | 15501029 |
| Beta-TC6 | IC50 | = | 48540.0 | nM | 4.31 | Concentration required for inhibition of glucose stimulated insulin release from... | 15501029 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15501029 | 10.1016/j.bmcl.2004.09.057 | Beta-TC6 | 2 |
| 15501029 | 10.1016/j.bmcl.2004.09.057 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine