Assay Detail
Functional
CHEMBL834738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibitory concentration required for repolarization of beta cell membrane potential in presence of 10 mM glucose
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.44 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112668 | — | — | 1 | 6.60 |
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.22 |
| CHEMBL185449 | — | — | 1 | 5.75 |
| CHEMBL183054 | — | — | 1 | 5.60 |
| CHEMBL180193 | — | — | 1 | 5.47 |
| CHEMBL183353 | — | — | 1 | 5.14 |
| CHEMBL182674 | — | — | 1 | 5.09 |
| CHEMBL181897 | — | — | 1 | 5.08 |
| CHEMBL185015 | — | — | 1 | 5.00 |
| CHEMBL360535 | — | — | 1 | 5.00 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.86 |
| CHEMBL181539 | — | — | 1 | - |
| CHEMBL183640 | — | — | 1 | - |
| CHEMBL360298 | — | — | 1 | - |
| CHEMBL183026 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112668 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL135191 | TIFENAZOXIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL185449 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL183054 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL180193 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL183353 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL182674 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL181897 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL185015 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL360535 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL181539 | — | IC50 | - | nM | - | |
| CHEMBL183640 | — | IC50 | - | nM | - | |
| CHEMBL360298 | — | IC50 | - | nM | - | |
| CHEMBL183026 | — | IC50 | - | nM | - |