Assay Detail
Functional
CHEMBL825079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against P388 cell line in mouse leukemia was determine
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.90 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191958 | GENZ-644282 | 1.0 | 1 | 9.52 |
| CHEMBL363340 | — | — | 1 | 9.15 |
| CHEMBL70790 | — | — | 1 | 9.00 |
| CHEMBL195107 | — | — | 1 | 9.00 |
| CHEMBL195377 | — | — | 1 | 8.70 |
| CHEMBL195805 | — | — | 1 | 8.52 |
| CHEMBL177804 | — | — | 1 | 8.40 |
| CHEMBL540712 | — | — | 1 | 8.40 |
| CHEMBL192411 | — | — | 1 | 8.22 |
| CHEMBL191245 | — | — | 1 | 8.22 |
| CHEMBL363839 | — | — | 1 | 8.22 |
| CHEMBL195332 | — | — | 1 | 8.22 |
| CHEMBL191909 | — | — | 1 | 7.85 |
| CHEMBL191032 | — | — | 1 | 7.80 |
| CHEMBL370251 | — | — | 1 | 7.42 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.35 |
| CHEMBL427002 | — | — | 1 | 7.30 |
| CHEMBL195792 | — | — | 1 | 7.22 |
| CHEMBL195611 | — | — | 1 | 6.70 |
| CHEMBL195102 | — | — | 1 | 6.64 |
| CHEMBL192202 | — | — | 1 | 6.64 |
| CHEMBL195148 | — | — | 1 | 6.60 |
| CHEMBL194932 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191958 | GENZ-644282 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL363340 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL70790 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL195107 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL195377 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL195805 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL177804 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL540712 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL192411 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191245 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL363839 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL195332 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191909 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL191032 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL370251 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL427002 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL195792 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL195611 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195102 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL192202 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL195148 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL194932 | — | IC50 | = | 250.0 | nM | 6.60 |