Assay Detail
Functional
CHEMBL826404
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Inhibitory concentration against TNF-alpha production in mouse macrophages
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.43 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190514 | — | — | 1 | 8.80 |
| CHEMBL192889 | — | — | 1 | 8.47 |
| CHEMBL193247 | — | — | 1 | 8.22 |
| CHEMBL363831 | — | — | 1 | 8.21 |
| CHEMBL363852 | — | — | 1 | 8.06 |
| CHEMBL364572 | — | — | 1 | 7.99 |
| CHEMBL371145 | — | — | 1 | 7.55 |
| CHEMBL364925 | — | — | 1 | 7.54 |
| CHEMBL193055 | — | — | 1 | 7.51 |
| CHEMBL192848 | — | — | 1 | 7.50 |
| CHEMBL191053 | — | — | 1 | 7.33 |
| CHEMBL192850 | — | — | 1 | 7.18 |
| CHEMBL193305 | — | — | 1 | 6.14 |
| CHEMBL191113 | — | — | 1 | 5.54 |
| CHEMBL434957 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190514 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL192889 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL193247 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL363831 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL363852 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL364572 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL371145 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL364925 | — | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL193055 | — | IC50 | = | 31.1 | nM | 7.51 |
| CHEMBL192848 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL191053 | — | IC50 | = | 47.2 | nM | 7.33 |
| CHEMBL192850 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL193305 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL191113 | — | IC50 | = | 2885.0 | nM | 5.54 |
| CHEMBL434957 | — | IC50 | = | 4457.0 | nM | 5.35 |