Assay Detail
Binding
CHEMBL827072
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Inhibition of 0.4 nM [3H]ketanserin binding to Serotonin 5-HT2A receptor from rat brain cortex
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.80 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192828 | — | — | 1 | 6.93 |
| CHEMBL189890 | — | — | 1 | 6.26 |
| CHEMBL191226 | — | — | 1 | 5.58 |
| CHEMBL362999 | — | — | 1 | 5.57 |
| CHEMBL365309 | — | — | 1 | 5.46 |
| CHEMBL193182 | — | — | 1 | 5.41 |
| CHEMBL364530 | — | — | 1 | 5.40 |
| CHEMBL191574 | — | — | 1 | - |
| CHEMBL192348 | — | — | 1 | - |
| CHEMBL426813 | — | — | 1 | - |
| CHEMBL191221 | — | — | 1 | - |
| CHEMBL189384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192828 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL189890 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL191226 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL362999 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL365309 | — | Ki | = | 3510.0 | nM | 5.46 |
| CHEMBL193182 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL364530 | — | Ki | = | 4010.0 | nM | 5.40 |
| CHEMBL191574 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL192348 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL426813 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL191221 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL189384 | — | Ki | > | 100000.0 | nM | - |