Assay Detail
ADMET
CHEMBL827153
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In vitro inhibitory concentration against Cytochrome P450 3A4
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.67 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364572 | — | — | 1 | 8.20 |
| CHEMBL192850 | — | — | 1 | 6.10 |
| CHEMBL192848 | — | — | 1 | 5.80 |
| CHEMBL191053 | — | — | 1 | 5.36 |
| CHEMBL371145 | — | — | 1 | 5.28 |
| CHEMBL364925 | — | — | 1 | 5.21 |
| CHEMBL193247 | — | — | 1 | 4.89 |
| CHEMBL193055 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364572 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL192850 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL192848 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL191053 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL371145 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL364925 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL193247 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL193055 | — | IC50 | = | 31800.0 | nM | 4.50 |