Assay Detail
Binding
CHEMBL827398
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Inhibition of [3H]DAMGO binding to mu-opioid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.35 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | 4.0 | 1 | 6.04 |
| CHEMBL541124 | — | — | 1 | 5.69 |
| CHEMBL536952 | — | — | 1 | 5.69 |
| CHEMBL536264 | — | — | 1 | 5.63 |
| CHEMBL539075 | — | — | 1 | 5.57 |
| CHEMBL539076 | — | — | 1 | 5.36 |
| CHEMBL557576 | — | — | 1 | 4.40 |
| CHEMBL536034 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL541124 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL536952 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL536264 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL539075 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL539076 | — | Ki | = | 4410.0 | nM | 5.36 |
| CHEMBL557576 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL536034 | — | Ki | = | 40600.0 | nM | 4.39 |