Assay Detail
Binding
CHEMBL827547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter
20
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.63 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81525 | — | — | 2 | 8.38 |
| CHEMBL306208 | — | — | 2 | 7.35 |
| CHEMBL371607 | — | — | 1 | 7.25 |
| CHEMBL80515 | — | — | 2 | 7.16 |
| CHEMBL195738 | — | — | 1 | 7.16 |
| CHEMBL365738 | — | — | 1 | 7.01 |
| CHEMBL192924 | — | — | 1 | 6.96 |
| CHEMBL80262 | — | — | 2 | 6.87 |
| CHEMBL366159 | — | — | 1 | 6.65 |
| CHEMBL82027 | — | — | 2 | 6.62 |
| CHEMBL2079586 | — | — | 2 | 6.12 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.98 |
| CHEMBL192195 | — | — | 1 | 5.94 |
| CHEMBL192035 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81525 | — | IC50 | = | 4.13 | nM | 8.38 |
| CHEMBL306208 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL81525 | — | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL371607 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL80515 | — | IC50 | = | 68.6 | nM | 7.16 |
| CHEMBL195738 | — | IC50 | = | 69.8 | nM | 7.16 |
| CHEMBL80515 | — | IC50 | = | 92.4 | nM | 7.03 |
| CHEMBL365738 | — | IC50 | = | 97.4 | nM | 7.01 |
| CHEMBL192924 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL80262 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL366159 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL82027 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL80262 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2079586 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL306208 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL370805 | COCAINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL192195 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL192035 | — | IC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL82027 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL2079586 | — | IC50 | = | 5060.0 | nM | 5.30 |