Assay Detail
Binding
CHEMBL827871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against porcine Na+/K+-ATPase
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium/potassium-transporting ATPase subunit alpha-1 (CHEMBL4131) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.97 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175806 | — | — | 2 | 7.17 |
| CHEMBL178993 | — | — | 1 | 7.12 |
| CHEMBL369515 | — | — | 1 | 5.72 |
| CHEMBL366906 | — | — | 1 | 5.39 |
| CHEMBL175981 | — | — | 1 | 4.92 |
| CHEMBL427124 | — | — | 1 | 4.30 |
| CHEMBL360685 | — | — | 1 | - |
| CHEMBL262795 | — | — | 1 | - |
| CHEMBL426228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175806 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL175806 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL178993 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL369515 | — | IC50 | = | 1888.0 | nM | 5.72 |
| CHEMBL366906 | — | IC50 | = | 4076.0 | nM | 5.39 |
| CHEMBL175981 | — | IC50 | = | 12105.0 | nM | 4.92 |
| CHEMBL427124 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL360685 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL262795 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL426228 | — | IC50 | > | 50000.0 | nM | - |