Assay Detail
Binding
CHEMBL827940
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CRF-stimulated cAMP production in cells expressing CRF1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.17 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333713 | — | — | 1 | 7.80 |
| CHEMBL184930 | — | — | 1 | 7.31 |
| CHEMBL184850 | — | — | 1 | 6.82 |
| CHEMBL183148 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333713 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL184930 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL184850 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL183148 | — | IC50 | = | 180.0 | nM | 6.75 |