Compound Detail
CHEMBL184930
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Basic Information
| ChEMBL ID | CHEMBL184930 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QBCMIBULNPRCOW-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
392.3
MW (Da)
5.34
ALogP
5
HBA
0
HBD
46.3
PSA (Ų)
0.57
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.31
Ki 1 meas. best 8.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 8.49 | 8.49 | 3.2 | 1 |
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 7.31 | 7.31 | 49.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 3.2 | nM | 8.49 | Binding affinity for recombinant human CRF1 receptor | 15225703 |
| Corticotropin-releasing factor receptor 1 | IC50 | = | 49.0 | nM | 7.31 | Inhibition of CRF-stimulated cAMP production in cells expressing CRF1 receptor | 15225703 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15225703 | 10.1016/j.bmcl.2004.05.056 | Corticotropin-releasing factor receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine