Assay Detail
Binding
CHEMBL827945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against human Opioid receptor mu 1 using [3H]diprenorphine as radio ligand
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.25 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38576 | ICI-199,441 | — | 1 | 7.28 |
| CHEMBL363718 | — | — | 1 | 7.13 |
| CHEMBL191987 | — | — | 1 | 6.98 |
| CHEMBL425897 | — | — | 1 | 6.82 |
| CHEMBL192718 | — | — | 1 | 6.50 |
| CHEMBL189683 | — | — | 1 | 6.36 |
| CHEMBL189643 | — | — | 1 | 6.32 |
| CHEMBL364907 | — | — | 1 | 6.24 |
| CHEMBL192998 | — | — | 1 | 6.15 |
| CHEMBL189430 | — | — | 1 | 6.11 |
| CHEMBL190600 | — | — | 1 | 6.06 |
| CHEMBL190766 | — | — | 1 | 5.99 |
| CHEMBL362741 | — | — | 1 | 5.98 |
| CHEMBL363822 | — | — | 1 | 5.98 |
| CHEMBL190353 | — | — | 1 | 5.97 |
| CHEMBL370538 | — | — | 1 | 5.97 |
| CHEMBL447185 | — | — | 1 | 5.96 |
| CHEMBL539685 | — | — | 1 | 5.91 |
| CHEMBL190030 | — | — | 1 | 5.72 |
| CHEMBL192734 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38576 | ICI-199,441 | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL363718 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL191987 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL425897 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL192718 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL189683 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL189643 | — | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL364907 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL192998 | — | Ki | = | 703.0 | nM | 6.15 |
| CHEMBL189430 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL190600 | — | Ki | = | 878.0 | nM | 6.06 |
| CHEMBL190766 | — | Ki | = | 1026.0 | nM | 5.99 |
| CHEMBL362741 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL363822 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL190353 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL370538 | — | Ki | = | 1062.0 | nM | 5.97 |
| CHEMBL447185 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL539685 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL190030 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL192734 | — | Ki | = | 2300.0 | nM | 5.64 |