Assay Detail
Binding
CHEMBL828024
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Inhibition against U2OS cells expressing rat Glucocorticoid receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.35 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186683 | — | — | 1 | 9.15 |
| CHEMBL433586 | — | — | 1 | 8.85 |
| CHEMBL363760 | — | — | 1 | 8.74 |
| CHEMBL366093 | — | — | 1 | 8.64 |
| CHEMBL186948 | — | — | 1 | 8.62 |
| CHEMBL186954 | — | — | 1 | 8.60 |
| CHEMBL183475 | — | — | 1 | 8.31 |
| CHEMBL184578 | — | — | 1 | 8.28 |
| CHEMBL362392 | — | — | 1 | 8.26 |
| CHEMBL186930 | — | — | 1 | 8.18 |
| CHEMBL362556 | — | — | 1 | 8.15 |
| CHEMBL181601 | — | — | 1 | 8.10 |
| CHEMBL186805 | — | — | 1 | 8.07 |
| CHEMBL184109 | — | — | 1 | 8.04 |
| CHEMBL360248 | — | — | 1 | 7.85 |
| CHEMBL182827 | — | — | 1 | 7.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186683 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL433586 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL363760 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL366093 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL186948 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL186954 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL183475 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL184578 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL362392 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL186930 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL362556 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL181601 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL186805 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL184109 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL360248 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL182827 | — | IC50 | = | 15.5 | nM | 7.81 |