Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL828255

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition constant against human Butyrylcholinesterase (hBuChE) using butyrylthiocholine (BuTCh) as substrate
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cholinesterase (CHEMBL1914) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM.
J Med Chem (2005) 48 : 2906 -2915
PubMed 15828829 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 61 5.92 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL192627 CHLORANIL — 1 6.57
CHEMBL8320 BENZOQUINONE — 1 5.69
CHEMBL364729 — — 1 5.50
CHEMBL365129 — — 1 -
CHEMBL195713 — — 1 -
CHEMBL191676 — — 1 -
CHEMBL372856 — — 1 -
CHEMBL192657 — — 1 -
CHEMBL192039 — — 1 -
CHEMBL366205 — — 1 -
CHEMBL425192 — — 1 -
CHEMBL191796 — — 1 -
CHEMBL365517 — — 1 -
CHEMBL192589 — — 1 -
CHEMBL191847 — — 1 -
CHEMBL191739 — — 1 -
CHEMBL192139 — — 1 -
CHEMBL191822 — — 1 -
CHEMBL435109 — — 1 -
CHEMBL191513 — — 1 -
CHEMBL192474 — — 1 -
CHEMBL193140 — — 1 -
CHEMBL192625 — — 1 -
CHEMBL371858 — — 1 -
CHEMBL192252 — — 1 -
CHEMBL192180 — — 1 -
CHEMBL370059 — — 1 -
CHEMBL193180 — — 1 -
CHEMBL193229 — — 1 -
CHEMBL192241 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL192627 CHLORANIL Ki = 268.0 nM 6.57
CHEMBL8320 BENZOQUINONE Ki = 2050.0 nM 5.69
CHEMBL364729 — Ki = 3200.0 nM 5.50
CHEMBL191676 — Ki > 100000.0 nM -
CHEMBL189727 — Ki > 100000.0 nM -
CHEMBL195713 — Ki > 100000.0 nM -
CHEMBL365129 — Ki > 100000.0 nM -
CHEMBL189988 BENZYLSULFONYLBENZENE Ki > 100000.0 nM -
CHEMBL190496 — Ki > 100000.0 nM -
CHEMBL363186 — Ki > 100000.0 nM -
CHEMBL192258 — Ki > 100000.0 nM -
CHEMBL365809 BUTANEDIONE Ki > 100000.0 nM -
CHEMBL90039 BENZOPHENONE Ki > 100000.0 nM -
CHEMBL371523 DIBENZOYLMETHANE Ki > 100000.0 nM -
CHEMBL190677 BENZOIN Ki > 100000.0 nM -
CHEMBL365982 — Ki > 100000.0 nM -
CHEMBL370299 — Ki > 100000.0 nM -
CHEMBL192595 — Ki > 100000.0 nM -
CHEMBL192648 — Ki > 100000.0 nM -
CHEMBL363855 — Ki > 100000.0 nM -
CHEMBL364734 — Ki > 100000.0 nM -
CHEMBL192809 2,3-PENTANEDIONE Ki > 100000.0 nM -
CHEMBL191625 — Ki > 100000.0 nM -
CHEMBL371371 — Ki > 100000.0 nM -
CHEMBL193228 — Ki > 100000.0 nM -
CHEMBL364588 — Ki > 100000.0 nM -
CHEMBL435109 — Ki > 100000.0 nM -
CHEMBL192241 — Ki > 100000.0 nM -
CHEMBL193229 — Ki > 100000.0 nM -
CHEMBL193180 — Ki > 100000.0 nM -
CHEMBL370059 — Ki > 100000.0 nM -
CHEMBL192180 — Ki > 100000.0 nM -
CHEMBL192252 — Ki > 100000.0 nM -
CHEMBL371858 — Ki > 100000.0 nM -
CHEMBL192625 — Ki > 100000.0 nM -
CHEMBL193140 — Ki > 100000.0 nM -
CHEMBL192474 — Ki > 100000.0 nM -
CHEMBL191513 — Ki > 100000.0 nM -
CHEMBL372856 — Ki > 100000.0 nM -
CHEMBL191822 — Ki > 100000.0 nM -
CHEMBL192139 — Ki > 100000.0 nM -
CHEMBL191739 — Ki > 100000.0 nM -
CHEMBL191847 — Ki > 100000.0 nM -
CHEMBL192589 — Ki > 100000.0 nM -
CHEMBL365517 — Ki > 100000.0 nM -
CHEMBL191796 — Ki > 100000.0 nM -
CHEMBL425192 — Ki > 100000.0 nM -
CHEMBL366205 — Ki > 100000.0 nM -
CHEMBL192039 — Ki > 100000.0 nM -
CHEMBL192657 — Ki > 100000.0 nM -