Assay Detail
Binding
CHEMBL828256
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Inhibition constant against rabbit liver carboxylesterase (rCE) using nitrophenyl acetate (o-NPA) as substrate
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 61 | 6.89 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193228 | — | — | 1 | 8.39 |
| CHEMBL362996 | — | — | 1 | 8.21 |
| CHEMBL191739 | — | — | 1 | 8.06 |
| CHEMBL192139 | — | — | 1 | 8.02 |
| CHEMBL191847 | — | — | 1 | 7.92 |
| CHEMBL192241 | — | — | 1 | 7.82 |
| CHEMBL192252 | — | — | 1 | 7.79 |
| CHEMBL193229 | — | — | 1 | 7.76 |
| CHEMBL192589 | — | — | 1 | 7.66 |
| CHEMBL192180 | — | — | 1 | 7.62 |
| CHEMBL191822 | — | — | 1 | 7.44 |
| CHEMBL193180 | — | — | 1 | 7.32 |
| CHEMBL192625 | — | — | 1 | 7.30 |
| CHEMBL366205 | — | — | 1 | 7.27 |
| CHEMBL192627 | CHLORANIL | — | 1 | 7.26 |
| CHEMBL370059 | — | — | 1 | 7.19 |
| CHEMBL435109 | — | — | 1 | 7.14 |
| CHEMBL189886 | BENZIL | — | 1 | 6.99 |
| CHEMBL193140 | — | — | 1 | 6.97 |
| CHEMBL371858 | — | — | 1 | 6.92 |
| CHEMBL192474 | — | — | 1 | 6.70 |
| CHEMBL365392 | — | — | 1 | 6.66 |
| CHEMBL191796 | — | — | 1 | 6.57 |
| CHEMBL192410 | — | — | 1 | 6.40 |
| CHEMBL365517 | — | — | 1 | 6.28 |
| CHEMBL191513 | — | — | 1 | 6.24 |
| CHEMBL365161 | — | — | 1 | 6.13 |
| CHEMBL195713 | — | — | 1 | 6.08 |
| CHEMBL364729 | — | — | 1 | 5.99 |
| CHEMBL191676 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193228 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL362996 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL191739 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL192139 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL191847 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL192241 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL192252 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL193229 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL192589 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL192180 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL191822 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL193180 | — | Ki | = | 47.9 | nM | 7.32 |
| CHEMBL192625 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL366205 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL192627 | CHLORANIL | Ki | = | 54.8 | nM | 7.26 |
| CHEMBL370059 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL435109 | — | Ki | = | 72.1 | nM | 7.14 |
| CHEMBL189886 | BENZIL | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL193140 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL371858 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL192474 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL365392 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL191796 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL192410 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL365517 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL191513 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL365161 | — | Ki | = | 736.0 | nM | 6.13 |
| CHEMBL195713 | — | Ki | = | 823.0 | nM | 6.08 |
| CHEMBL364729 | — | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL191676 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL371523 | DIBENZOYLMETHANE | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL192258 | — | Ki | = | 4930.0 | nM | 5.31 |
| CHEMBL370299 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL371371 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL364734 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL284028 | 2,3-DIHYDROXY-6,7-DICHLOROQUINOXALINE | Ki | > | 100000.0 | nM | - |
| CHEMBL192648 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL192595 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL365982 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL425192 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL190677 | BENZOIN | Ki | > | 100000.0 | nM | - |
| CHEMBL192039 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL192657 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL372856 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL90039 | BENZOPHENONE | Ki | > | 100000.0 | nM | - |
| CHEMBL365809 | BUTANEDIONE | Ki | > | 100000.0 | nM | - |
| CHEMBL365129 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL189988 | BENZYLSULFONYLBENZENE | Ki | > | 100000.0 | nM | - |
| CHEMBL190496 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL363855 | — | Ki | > | 100000.0 | nM | - |